Miconazole is an imidazole antifungal drug which is available in the different pharmaceutical dosage forms through various routes of administration, such as oral, topical and systemic. The drug is a Broad-spectrum antifungal agent and it is used in the treatment of superficial or systemic fungal infections. This article reviews the current analytical methods for identification and quantitative determination of Miconazole in samples. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of Miconazole as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the time period from 1978 to 2012 during many analytical methods including spectrophotometric methods like UV and derivative; and chromatographic method including HPLC, HPTLC, GC and alternative method like Voltammetry, Potentiometric method were reported. The application of these methods for the determination of Miconazole in pharmaceutical formulations and biological samples has also been discussed.
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